PharmacologyPharmacology is now firmly established as a world wide best-selling and highly acclaimed textbook for medical and science students. Its successful approach emphasies the mechanisms by which drugs act and relates these to the overall pharmacological effects and clinical uses. It sets out for the reader a clear route from a molecular understanding of receptors and drug actions, to the therapeutic uses of the most important groups of drugs. For the Fifth Edition the text has been completely updated, incorporating significant new information published in the last few years, while obsolete material has been removed. New agents are fully discussed as well as extensions of basic knowledge which presage further drug development. Book jacket. |
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Page 512
... GABA - aminotransferase . There are three main EAA receptor subtypes ( Table 24.3 ) : -NMDA -AMPA / kainate ... ( GABA ) Synthesis , storage and function GABA occurs in brain tissue , but not in other mam- malian tissues , except in trace ...
... GABA - aminotransferase . There are three main EAA receptor subtypes ( Table 24.3 ) : -NMDA -AMPA / kainate ... ( GABA ) Synthesis , storage and function GABA occurs in brain tissue , but not in other mam- malian tissues , except in trace ...
Page 514
... GABA and glycine GABA is the main inhibitory transmitter in the brain . It is present fairly uniformly throughout the brain ; there is very little in peripheral tissues . GABA is formed from glutamate , by the action of GAD ( glutamic ...
... GABA and glycine GABA is the main inhibitory transmitter in the brain . It is present fairly uniformly throughout the brain ; there is very little in peripheral tissues . GABA is formed from glutamate , by the action of GAD ( glutamic ...
Page 555
... GABA . So far no such substance has been definitely identified , though there has been much speculation ( see Barbaccia et al . 1988 ) . One candidate , now known to be an artifact , was ethyl B - carboline 3 - carboxylate ( B - CCE ) ...
... GABA . So far no such substance has been definitely identified , though there has been much speculation ( see Barbaccia et al . 1988 ) . One candidate , now known to be an artifact , was ethyl B - carboline 3 - carboxylate ( B - CCE ) ...
Contents
SECTION ONE 16 Hemostasis and Thrombosis | 331 |
The Respiratory System | 351 |
General Principles | 367 |
Copyright | |
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acetylcholine acid action activity agents agonists anesthetics animals antagonists appears associated binding block blood body brain Ca2+ calcium cardiac cause cells central changes channels Chapter chemical clinical compounds concentration decrease dependence depression disease dopamine dose drugs effects enzyme evidence example excreted factor function given glucose half-life heart hormone important increase inhibition inhibitors injection insulin interaction involved known less liver mainly measured mechanism mediators membrane metabolism molecules myocardial infarction nerve neurons norepinephrine normal occurs orally organs pain pathway patients peptide Pharmacol pharmacological phase plasma potential pressure prevent produce protein reactions receptors reduced regulation release renal response result role secretion selective shown similar smooth muscle specific stimulation structure studies substances synthesis Table terminals therapeutic therapy tion tissues toxicity transmission transmitter treat treatment tubocurarine types unwanted effects usually various vascular