Retroviruses: Molecular Biology, Genomics and Pathogenesis

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Reinhard Kurth, Norbert Bannert
Horizon Scientific Press, Jan 1, 2010 - Science - 454 pages
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Retroviruses comprise a diverse family of enveloped RNA viruses, remarkable for their use of reverse transcription of viral RNA into linear double stranded DNA during replication and the subsequent integration of this DNA into the genome of the host cell. Members of this family include important pathogens such as HIV-1, feline leukemia, and several cancer-causing viruses. However, interest in these viruses extends beyond their disease-causing capabilities. For example, research in this area led to the discovery of oncogenes, a major advance in the field of cancer genetics. Studies of retroviruses have contributed greatly to our understanding of mechanisms that regulate eukaryotic gene expression. In addition, retroviruses are proving to be valuable research tools in molecular biology and have been used successfully in gene therapy (e.g. to treat X-linked severe combined immunodeficiency). Written by the top retroviral specialists, this book reviews the genomics, molecular biology, and pathogenesis of these important viruses, comprehensively covering all the recent advances. Topics include: host and retroelement interactions * endogenous retroviruses * retroviral proteins and genomes * viral entry and uncoating * reverse transcription and integration * transcription * splicing and RNA transport * pathogenesis of oncoviral infections * pathogenesis of immunodeficiency virus infections * retroviral restriction factors, molecular vaccines, and correlates of protection * gammaretroviral and lentiviral vectors * non-primate mammalian and fish retroviruses * simian exogenous retroviruses * and HTLV and HIV. It is essential reading for every retrovirologist and it is a recommended text for all virology and molecular biology laboratories.
  

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Contents

An Everlasting War Dance Between Retrotransposons and their Metazoan Hosts
1
Endogenous Retroviruses
35
Retroviral Particles Proteins and Genomes
71
Retroviral Entry and Uncoating
107
Reverse Transcription and Integration
129
Transcription Splicing and Transport of Retroviral RNA
161
Assembly and Release
187
Transmission and Epidemiology
217
Pathogenesis of Immunodeficiency Virus Infections
269
Retroviral Restriction Factors
285
Molecular Vaccines and Correlates of Protection
309
Gammaretroviral and Lentiviral Vectors for Gene Delivery
347
Nonprimate Mammalian and Fish Retroviruses
371
Simian Exogenous Retroviruses
395
HTLV and HIV
417
Index
445

Pathogenesis of Oncoviral Infections
237

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