Bile Acids and Hepatobiliary Diseases - Basic Research and Clinical Application
G. Paumgartner, A. Stiehl, W. Gerok
Springer, Jun 30, 1997 - Medical - 352 pages
Since the last International Bile Acid Meeting in San Diego in 1994, new advances have been made in the understanding of bile acid metabolism and transport. The cytotoxic as well as the therapeutic effects of specific bile acids have been further explored and the beneficial effects of ursodeoxycholic acid in various chronic cholestatic conditions have been substantiated. Much basic and clinical research has been conducted to unravel the underlying mechanisms of action. This volume, the proceedings of Falk Symposium No. 93 (XIV International Bile Acid Meeting), held in Freiburg-im-Breisgau, Germany, October 22-24, 1996, is dedicated to both basic and clinical aspects of bile acid research related to the role of bile acids in hepatobiliary diseases.
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Identification of a unique inborn error in bile acid conjugation
a key cytochrome P450 in bile
27 other sections not shown
ABC proteins acid transport system activity amino acid apoptosis ATP-dependent basolateral bile acid synthesis bile acid transport bile duct bile salts biliary bile acid biliary lipid secretion Biochem Biol Chem Boyer JL canalicular canalicular membrane carboxyfluorescein cathepsin CDCA cDNA cells chenodeoxycholic acid cholate cholestasis cholestatic cholesterol cholic acid Clin Invest cloning concentrations cytosolic decreased deoxycholic acid effects of bile encoding enterohepatic circulation enzyme excretion expression function gallstone Gastroenterology gene hepatic hepatocellular hepatocytes Hepatology human hydrophobic Hylemon PB IBAT ileal bile acid increased induced inhibition inhibitors intracellular isolated Kramer lipid Lipid Res liver disease mdr2 MDR3 mechanism Meier PJ metabolism micelles mmol/L molecular mRNA mRNA levels MRP1 mutations Na+-dependent Na+/bile acid co-transporter Ntcp pathway patients peptides phospholipid photoaffinity labelling Physiol polypeptide primary biliary cirrhosis protein kinase rabbit ileal rat hepatocytes rat liver regulation sequence serum sodium-dependent specific sterol studies substrate treatment TUDCA UDCA ursodeoxycholic acid