Design Principles for the Immune System and Other Distributed Autonomous Systems (Google eBook)

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Department of Applied Mathematics and Computer Science Lee A. Segel Professor of Mathematics, Department of Immunology both at Weizmann Institute Irun R. Cohen Professor of Immunology
Oxford University Press, Jun 14, 2001 - Mathematics - 428 pages
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Design Principles for the Immune System and Other Distributed Autonomous Systems is the first book to examine the inner workings of such a variety of distributed autonomous systems--from insect colonies to high level computer programs to the immune system. It offers insight into the fascinating world of these systems that emerge from the interactions of seemingly autonomous components and brings us up-to-date on the state of research in these areas. Using the immune system and certain aspects of its functions as a primary model, this book examines many of the most interesting and troubling questions posed by complex systems. How do systems choose the right set of agents to perform appropriate actions with appropriate intensities at appropriate times? How in the immune system, ant colonies and metabolic networks does the diffusion and binding of a large variety of chemicals to their receptors permit coordination of system action? What advantages drive the various systems to complexity, and by what mechanisms do the systems cope with the tendency toward unwieldiness and randomness of large complex systems?
  

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Contents

Introduction to the Immune System
3
Cytokines A Common Signaling System for Cell Growth Inflammation Immunity and Differentiation
29
Th1Th2 Effector Choice in the Immune System A Developmental Program Influenced by Cytokine Signals
79
Oral Tolerance
95
An Introduction to Immunoecology and Immunoinformatics
125
The Creation of Immune Specificity
151
Diversity in the Immune System
161
T Cells Obey the Tenets of Signal Detection Theory
185
Distributed Anarchic Immune Organization Semiautonomous Golems at Work
241
New Approaches to Complex Chemical Reaction Mechanisms
261
Control Mechanisms for Distributed Autonomous Systems Insights from the Social Insects
281
Task Allocation in Ant Colonies
293
Biologicaliy Motivated Distributed Designs for Adaptive Knowledge Management
305
Analogy Making as a Complex Adaptive System
335
Immunology as Information Processing
361
Index
389

Diffuse Feedback from a Diffuse Informational Network In the Immune System and Other Distributed Autonomous Systems
203
Multistep Navigation and the Combinatorial Control of Cell Positioning A General Model for Generation of Living Structure Based on Studies of Im...
227

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