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abdominal abstinence action afferent innervation agents agonist activity analgesia analgesic analgesic effect animal antagonist analgesics benzomorphan biliary pressure brain buprenorphine butorphanol cancer carcinomas catheter Cervero chronic clinical deep pain disease dosage doses drugs endogenous endorphin enkephalin epidural morphine epidural narcotics evoked ex-addict volunteers experimental Houde hyperalgesia Iggo increase injection inputs internal organs intrathecal Jasinski Kosterlitz Martin mechanisms of visceral metastases morphine-like muscle myelinated Nalbuphine nalorphine nalorphine-like naloxone narcotics nerve neurones nociceptive nociceptors noxious stimuli observed opiate receptor opioid peptides pain pathways pain relief parenteral partial agonist pentazocine Pharmac pharmacology potential produced properties Propiram pure agonist receptor population referred pain reflexes respiratory depression response sensory pathways sensory receptors skin somatic spinal cord studies subarachnoid superficial symptoms terminal patient Ther therapeutic therapy thoracic tissue treatment Twycross Ventafridda visceral afferent visceral afferent fibres visceral pain visceral receptors visceral sensory visceral stimulation viscerosomatic convergence viscus