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48 hours ACTH activity acute administration adrenal albumin allergic reactions anaphylactic shock anaphylaxis animals antibiotic antibody antigen antigen-antibody antihistamines antitoxin Arthus atopic dermatitis authors bacilli Benadryl blood bronchial asthma Brooklyn capillary cent chlorpromazine clinical complement cortisone count daily developed disease dosage dose drug eczema edema effect emphysema eosinophilia epinephrine eruption erythema experiments extract fraction gamma globulin given guinea pigs hay fever heparin histamine hormone hydrocortisone hydrocortisone ointment hypersensitivity immunized increased inhibited injection intervals intracutaneous tests intraperitoneal intravenous lesions leucocyte levels liver lung lymph node mice mild negative normal novobiocin observed obtained occurred oral oxygen oxytetracycline passive patch test patients penicillin plasma platelets positive reactions potassium prednisolone Prednisone Proc produced protein pruritus pulmonary purpura rabbits rats response sensitivity sera serum showed skin test solution steroids streptomycin studies subcutaneous symptoms therapy tion tissue titer toxoid treated treatment tuberculin Tyzine vaccine vital capacity vitro weeks