Eicosanoids and ReproductionK. Hillier The original series, Advances in Prostaglandin Research, edited by Sultan M. M. Karim, was published by MTP Press in three volumes in 1975 and 1976. A glance at those books illustrates the progress that has been made since then. The thromboxanes were mentioned twice (first publication 1975) and prostacyclin not once (first publication 1976); leukotrienes were only on the horizon. The amazing generation of research data in the last 10-15 years has given new, broad insights into many areas, including asthma, inflammation, renal, cardiovascular and gastrointestinal diseases and in reproduction, and has led in some instances to real clinical benefit. This series, Advances in Eicosanoid Research, reflects the current understanding of prostaglandins , thromboxanes and leukotrienes. The aim is to provide an introductory background to each topic and the most up-to-date information available. Although each book stands alone, the eicosanoids cut across many boundaries in their basic actions; selected chapters from each book in the series will provide illuminating and productive information for all readers which will advance their education and research. In the production of this series, I must acknowledge with pleasure my collaboration with editors and authors and the patient endeavours of Dr Michael Brewis and the staff at MTP Press. KEITH HlLUER University of Southampton England ix Preface This book is an appraisal of areas in human reproduction where eicosanoid studies (prostaglandins, leukotrienes and thromboxanes) are contributing to physiological and pathological awareness and clinical advances. |
Contents
G Ekman M D Mitchell | 2 |
The Bartholin Building UCSD Medical Center | 22 |
Eicosanoids menstruation and menstrual disorders | 30 |
Copyright | |
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abortion action activity administration amniotic fluid arachidonic acid arterial Biochem Biol blastocyst bleeding blood flow blood loss Bygdeman c-AMP cervical ripening circulation clinical collagen contractility corpora lutea corpus luteum cyclo-oxygenase decreased dilatation dose ductus arteriosus dysmenorrhoea early pregnancy eicosanoids Endocrinol Endocrinology endometrium enzymes extra-amniotic Fertil fetal membranes follicles gestation Gynecol hormone hypertension implantation increase incubation indomethacin induction of labour infusion inhibition inhibitors injection intrauterine intravenous leukotrienes levels LH release lipoxygenase luteal cells luteinizing luteolysis maternal mechanism menstrual cycle metabolism metabolites Mitchell myometrial myometrium normal Obstet oestradiol oestrogen onset ovarian ovary ovulation oxytocin pathways patients pessary PGE2 PGF2 phospholipase placenta plasma platelet pre-eclampsia pre-eclamptic placenta pregnancy progesterone prostacyclin prostacyclin and thromboxane prostacyclin production prostaglandin biosynthesis prostaglandin F₂ prostaglandin production prostaglandin synthesis prostanoids pulmonary rabbit receptors Reprod role sheep steroid stimulation studies thromboxane tissue treatment trimester Turnbull umbilical uterine cervix uterus vaginal vitro women