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anti anti-HCV antigen Arthritis Rheum assay associated autoantibodies autoimmune diseases B-cell biopsy bone marrow chronic hepatitis cirrhosis classiﬁcation Clin clinical conﬁrmed controls correlation criteria cryocrit cryoglo cryoglobulins cryoprecipitate cytokines deﬁned detected diagnosis disease activity dose drugs effect ELISA epitope essential mixed cryoglobulinemia evaluated ﬁndings ﬁrst gene genotypes HCV infection HCV-RNA hepatitis C virus hepatocellular carcinoma human identiﬁed idiotype immune Immunol Immunology inﬁltrates inﬂammatory interferon involvement Italy laboratory levels liver disease LONGOMBARDO lymphocytes lymphoma markers MC patients mice monoclonal antibodies mononuclear cells non-A patients with rheumatoid PBMC peptides peripheral blood positive present prevalence protein RA patients receptor renal response rheumatoid arthritis rheumatoid arthritis RA rheumatoid factor Rheumatol Rheumatology role sequence sera serological serum signiﬁcant signiﬁcantly speciﬁc syndrome synovial synovium systemic lupus erythematosus therapy tissue treatment vasculitis viral