Parkinson's disease: neurobehavioral aspects
Behavioral symptoms are an integral part of Parkinson's disease. In the past decade there has been an enormous amount of research on the nature of these disturbances, their underlying neural basis, and methods of assessment. This book provides an up-to-date review of neuropsychological deficits, depression, and treatment-related behavioral disorders associated with Parkinson's disease. Each section is a balanced presentation of both theoretical and practical issues. From a theoretical perspective, study of the neurobehavioral features of Parkinson's disease has contributed to our understanding of the subcortical structures and neurotransmitter systems related to human cognitive and emotional functions. From a practical perspective, behavioral symptoms represent a major treatment challenge. The advent of levodopa has created a population of older and more chronically disabled Parkinson patients, and has made it more imperative to understand the illness. Proper management of patients requires adequate methods for assessing behavioral changes, understanding the relationship of the behavior to the neurobiology of the disease, and being aware of therapeutic options.
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The Historical Background of Behavioral Studies
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abnormalities adrenal Agid Alzheimer's disease Ann Neurol anticholinergic antidepressant antiparkinsonian Arch Neurol assessment associated atrophy basal ganglia behavioral bradykinesia bradyphrenia Brain caudate cerebral changes cholinergic Clin clinical cognitive deficits cognitive function cognitive impairment colleagues controls correlated cortex cortical criteria Cummings Dementia in Parkinson's dementia in PD deprenyl diagnosis differences disturbances dopa dopamine dopaminergic drugs Dubois dysfunction dyskinesia electroconvulsive electroconvulsive therapy etal fluctuations frontal lobe hallucinations Huber Huntington's disease idiopathic improvement Jankovic L-dopa latency lesions levodopa locus ceruleus Mayeux medications memory mental metabolism mood motor symptoms Neurol Neurosurg Psychiatry Neurology neuronal loss neuropsychological nondemented PD patients normal onset Parkin Parkinson's disease parkinsonian pathology patients with dementia patients with Parkinson's patients with PD PD patients PD symptoms percent performance pergolide prevalence Psychiatry Raven Press receptor reported response scores serotonin severity significantly Starkstein striatal striatum studies subcortical dementia substantia nigra syndrome tasks therapy treatment tremor visual visuospatial