Tumor Necrosis Factor-alpha- and Interleukin-1-induced Cellular Responses: Coupling Proteomic and Genomic Information
ProQuest, 2007 - 205 pages
The pro-inflammatory cytokines, Tumor Necrosis Factor-alpha (TNFalpha) and Interleukin-1 (IL-1) mediate the innate immune response. Dysregulation of the innate immune response contributes to the pathogenesis of cancer, arthritis, and congestive heart failure. TNFalpha and IL-1 induced changes in gene expression are mediated by similar transcription factors; however, TNFalpha and IL-1 receptor knock-out mice differ in their sensitivities to a known initiator (lipopolysaccharide, LPS) of the innate immune response. The contrasting responses to LPS indicate that TNFalpha and IL-1 regulate different processes. A large-scale proteomic analysis of TNFalpha and IL-1 induced responses was undertaken to identify processes uniquely regulated by TNFalpha and IL-1. When combined with genomic studies, our results indicate that TNFalpha, but not IL-1, mediates a cell cycle arrest.
What people are saying - Write a review
We haven't found any reviews in the usual places.
CXXC Finger Protein 1 Upregulates Maintenance DNA Methylation
Jill Sergesketter Butler
Limited preview - 2007
Functional Analysis of Two Novel DNA Repair Factors, Metnase and Pso4
Brian Douglas Beck
No preview available - 2008
apoptosis ATP binding BARD1 biological process unknown calcium ion binding catabolism CCL2 CDC6 cell adhesion cell cycle cell proliferation cellular component unknown complex cytokine cytoplasm cytoskeleton DNA replication electron transport etal Eukaryota extracellular space FAF1 Gene GO Term GO Term Regulation_TNF GO Term Z-score hydrolase activity ID Gene GO integral to membrane integral to plasma IRAK1 JAG1 lipid metabolism metal ion binding MITOCHONDRIAL negative regulation nucleotide nucleotide binding nucleus oxidoreductase activity peptides plasma membrane PLOD1 polymerase II promoter positive regulation PPP2CA protein binding protein biosynthesis Protein ID Gene protein kinase protein levels proteomic receptor activity regulation of cell regulation of transcription RNA polymerase sensu Eukaryota signal transducer activity signal transduction SPLICE ISOFORM structural constituent SUBUNIT Term Regulation_TNF Regulation_IL1 Term Z-score TvU TGFB1 TLR2 transcription DNA-dependent transcription factor transcription factor activity transcription from RNA transferase activity transporter activity TvU Z-score IvU ubiquitin Z-score Z-score TvU Z-score zinc ion binding