Intermediate Filaments (Google eBook)

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Springer Science & Business Media, Jun 7, 2007 - Science - 160 pages
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Intermediate Filaments focuses on desmin and other intermediate filaments in disease and health. This new volume will serve as a resource for graduate students and researchers in the field.
  

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Contents

Desmin and Other Intermediate Filaments in Normal and Diseased Muscle
1
Desmin and Other IF Proteins in Different Muscles
2
Functions of Desmin in Striated Muscles
4
Function of Desmin in Smooth Muscles
5
DesminRelated Myopathies DRM
6
Intermediate Filaments in Astrocytes in Health and Disease
10
GFAP and Its Regulation
11
Formation of IFs in Astroglial Cells
13
Expression of the K6 Genes
87
Expression and Partners
89
Transcriptional Regulation of Keratin Gene Expression
93
Regulation of K14
95
Regulation of K15
96
Regulation of K4 and K13
97
Regulation of K3 and K12
98
Regulation of Hair Keratins
99

Astrocyte IFs CNS Trauma and Regeneration
16
Astrocyte IFs and Resistance to Mechanical Stress
22
Astrocyte IFs Osmotic Stress and IschemiaHypoxia
25
GFAP Mutations and Alexander Disease
26
Neuronal Intermediate Filaments and Neurodegenerative Diseases
35
Neuronal Intermediate Filament Proteins
36
Neuronal IFs in Neurodegenerative Diseases
38
Neurofilaments Phosphorylation and Signal Transduction
52
Neurofilaments and Axonal Caliber
55
Neurofilaments and Their Associated Kinases
56
Neurofilament Tall Domain Phosphorylation
57
Axonal Transport of Neurofilaments
58
Phosphorylation of NFs and Disease
59
Neurofilaments and Signal Transduction Pathways
60
Keratin Intermediate Filaments and Diseases of the Skin
74
Candidate Genes in Other Epithelia
75
From Candidate Genes to Candidate Diseases
77
Keratin Filaments as Tensile Structures
78
Significance of Keratin Role in Skin Fragility Disorders
79
The Keratin K6 Minifamily of Genes
83
Conservation of Sequence in the K6 Polypeptides
84
Regulation of Keratin Gene Expression by Growth Factors and Cytokines
101
Specific Transcription Factors Implicated in Regulation of Transcription of Keratin Genes
103
Conclusions and Future Directions
105
Simple Epithelial Keratins Expression Function and Disease
110
Suggested Functions of Simple Epithelial Keratins
111
Simple Epithelial Keratin Proteins and Disease
114
Altered Simple Epithelial Keratin Expression and Cancer
115
Keratins as Targets in and Modulators of Liver Diseases
120
Alterations of the Keratin Cytoskeleton in Human Liver Diseases
121
Animal Models to Study Hepatocystic Keratin Alterations
122
Mallory Bodies as a Product of the Cellular Response to Misfolded Keratin
124
How Can Keratins Influence Toxic Cell Injury?
125
Mutations of Keratin Genes and Liver Diseases
127
The Search for Specific Keratin Functions The Case of Keratin K10
131
Keratin K10 Assembly and Dynamics
132
Keratin K10 Inhibits Cell Proliferation
134
Transgenic Mice Models to Study K10 Functions
138
The Paradigms of K10 Knock Out Model
139
Reconciling Hypotheses
141
Index
146
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Page 129 - Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man. including those of Parkinson's disease. Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and Mallory bodies in alcoholic liver disease. J. Pathol.

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