Control of Growth Factors and Prevention of Cancer
It is now apparent that several fields of investigation are converging upon each other as the goal of finding a practical way to prevent cancer is pursued. The present monograph represents the efforts of an interdisciplinary ESO Task Force that was convened to assess interactions of peptide growth factors and steroid-like molecules in the prevention of cancer. Each of the participants in the Task Force represents a differentscientific discipline, and the monogrph is intended to be a synthesis of their different approaches to the common problem of cancer prevention. It is hoped that the reader will find this monograph to be of use in the evaluation of both preclinical and clinical approaches to the major issues that face us in chemoprevention. It is clear that prevention of cancer is an idea whose time has come, and the problem now is to implement the most effective approaches toward achieving the desired goals.
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Steroids Retinoids and their Mode of Action
Sequentially in the Induction of Milk Protein Gene Expression
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Acad Sci USA action amino acids androgen receptors B-casein promoter Biol breast cancer c-myc Cancer Res carcinogenesis cell line cellular Chambon chemoprevention clinical differentiation DNA binding domain ductal effects EGF receptor epidermal growth factor epithelial cells epithelium fibroblast function gene expression gestodene glucocorticoid receptor Hardcover ISBN HC11 cells histological hormone receptors induced inhibition interactions isoforms kinase lesions LNCaP malignant mammary epithelial cells mechanism metastatic milk protein mitogenic molecular molecules mouse mRNA mutated Natl Acad Sci neoplastic normal nuclear receptors oestrogen oncogene pathways peptide population premalignancy preneoplastic prevention Proc Natl Acad prolactin receptor proliferation proliferative prostate cancer prostate cancer cells prostate epithelial cells rat prostate rat ventral prostate recognised region regulation response element retinoic acid receptor retinoids sequence signal transduction specific Sporn MB steroid receptor studies synthesis tamoxifen target genes TGF-B TGF-beta therapy tion tissue transcription factor transcriptional activation transforming growth factor tumour vitro women