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Ab-Ag complexes activity affinity agglutination alleles allergic alloantigens allografts allotypes amino acid anaphylaxis animals anti antibodies antigenic antisera antiserum Arthus assay autoimmune bacteria binding block blood group cell surface cell-mediated immunity combining sites concentration corresponding cross-reacting cules delayed-type detected determinants differentiation disease donor doses effective elicited enzymes formation fragments genes genetic grafts guinea pig hapten heavy chains histamine histocompatibility Ags human hypersensitivity idiotype Ig molecules immune responses immunogen immunoglobulins Immunol immunological inbred individuals induced inhibit injected lesions leukocytes levels ligand light chains locus lymphocytes lymphoid cells macrophages mast cells membrane mice mole molecules mouse myeloma protein normal plasma cells polysaccharides precipitation precipitin reaction probably produce rabbit react reagins receptors recipient red cells residues S-S bonds sensitized sera serum serum sickness skin soluble specific spleen sponse stimulate strains subclasses substance thymus tion tissue titer tolerance transplantation tumor univalent virus