Pharmacokinetic Analysis: A Practical Approach

Front Cover
CRC Press, Jun 7, 1996 - Medical - 568 pages
0 Reviews
This insightful work provides a useful introduction to the very large and important field of pharmacokinetics. The authors have selected the Time Constant Approach as a unifying view within which to present important application areas. In addition to providing consistency, their approach provides the novice with an intuitive time view that is meaningful from the outset. This approach allows one to get a "feel" for the data and to relate it to other data in a direct and accessible manner.
The Time Constant Approach provides a synthesis of the noncompartmental and compartmental methods, with the advantages of both. It starts by defining a physiologically meaningful model based on the pharmacokinetic processes involved. The Time Constant Approach recognizes pharmacokinetics as a number of processes that move drugs between physiological compartments, each process occurring at its own characteristic length of time, to correlate descriptive pharmacokinetic events with time constants of pharmacokinetic processes. While analogous to the three most common testing approaches for pharmacokinetics (the noncompartmental, compartmental and statistical moment approaches) the Time Constant Approach possesses many advantages.
  

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

Introduction
3
Time Constant Approach
15
Evaluation of Time Constants
61
Scaling of Time Constants among
77
Influence of Administration Route
93
Influence of Formulation
121
Influence of Dosage
143
Pharmacokinetics of Sustained
167
Relationship between Pharmacokinetics
273
Influence of Food on Pharmacokinetics
315
Effects of Drug Interactions
345
Influence of Age on Pharmacokinetics
369
Difference in Pharmacokinetics
393
Special Pharmacokinetic Considerations
407
Special Pharmacokinetic Considerations
439
Special Pharmacokinetic Considerations
467

ABSORPTION DISTRIBUTION
189
Drug Distribution into Tissue
213
Pharmacokinetics of Metabolites
237
Evaluation of Mean Residence Times from
499
Index
543
Copyright

Common terms and phrases

Bibliographic information