Principles of Protein StructureNew textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical thermodynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from a real lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research which is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases the availability of texts in active research areas should help stimulate the creation of new courses. |
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a-helix active adenylate kinase amino acid amino acid changes amino acid residues amino acid sequence angles antiparallel atoms backbone binding energy Biol biological BPTI C-terminal catalytic cell chain fold chemical chymotrypsin collagen comparison conformation contains corresponding covalent cytochrome data base dehydrogenase density derived disulfide bonds electron enzyme evolution evolutionary example folding process formation free energy frequencies function gene globular proteins haem helices helix hemoglobin homologous hydrogen bonds immunoglobulins indicated interactions kcal/mol ligands loop matrix membrane moiety molecular molecules mutation myoglobin myosin native neighborhood correlation nonpolar nucleotide observed pathway peptide bond phosphoryl polypeptide chain position prediction propensities proteases protein differentiation protein structure reaction refolding residue type reverse turns ribonuclease ribosome secondary structure sheet topologies side chains solvent specific ẞ-sheet stability strands structural domains substrate subunits supersecondary structures surface Table three-dimensional structure tion transition tropomyosin trypsin Waals Zimm-Bragg model