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Acad anti anti-idiotypic antibodies antigenic determinants antigenic drift antisera assay autoantibodies autoimmune binding bone marrow cancer carcinoembryonic antigen carcinoma cell hybrids cell surface antigen characterization Clin clinical clones cross-reactive cytotoxic detection diagnosis differentiation antigen disease enzyme epitopes function fused fusion genes glycoprotein haemagglutinin hormone HTLV human hybridomas human MCA human T-cell hybridoma technology hybridomas idiotype immune response immunoassay immunoglobulin Immunol Immunology infection influenza inhibited interferon interleukin ISSN leukaemia lymphocytes lymphokine lymphoma macrophages malignant MCA directed MCA reacted MCA specific MCA were produced melanoma membrane Methods mice molecule monoclonal antibodies mouse myeloma cells murine murine MCA Natl neutralizing normal parasite patients peripheral blood poliovirus polyclonal Proc protein radioimmunoassay reagents receptor recognized report MCA ricin serological serum shown spleen cells sporozoite strains structure subsets suppressor T-cell hybridomas T-cell line technique tissue toxin tumour tumour cells vaccine viral virus viruses vitro vivo