HCV and related liver diseases
More than 2 million people in Japan have chronic hepatitis C and many of them will lose their lives to liver cirrhosis or complications of hepatocellular carcinoma. Hepatitis C virus-related diseases are a serious concern both in developing countries and in Japan and the United States, where the number of patients is also in the millions. Therapeutic modalities recently developed in Japan, including interferon therapy and nutritional supportive therapy, are gaining worldwide acceptance. At this critical juncture, HCV and Related Liver Diseases presents new information on etiology, pathology, diagnosis, and therapy. Viral hepatitis was the theme of the Yamaguchi Symposium on Liver Disease, meeting in December 1998 and attended by leading hepatologists and virologists. Collected in this volume are the papers from the symposium, providing a valuable resource for hepatologists, gastroenterologists, and others working to understand and treat viral hepatitis.
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Different Quasispecies of Hepatitis C Virus in Human Serum
Natural Variation in Translational Activities of
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amino acid amino acid sequence analysis anti-HCV antibodies antiviral assay biochemical capsid chronic active hepatitis chronic hepatitis clinical coding region codons combination therapy cumulative incidence detected domain E2 region genome genotype given IFN HCV genome HCV genotypes HCV infection HCV RNA level HCV-H HCV-N HCV-related hepatitis C virus hepatocellular carcinoma Hepatology histological IFN therapy incidence of HCC interferon interferon therapy Japan Kurume University liver cirrhosis liver disease mutations negative-strand non-A non-B nonresponders NS4A nucleotide nucleotide sequence nucleotide substitution patterns oral cancer Osaka outer group sequence patients with chronic PBMCs plasmids polyprotein positions of codons primers protein proteinase quasispecies relative substitution frequencies replication response to interferon ribavirin risk of HCC RT-PCR School of Medicine serum HCV RNA Shimotohno six clones subtype sustained response tion tissue Tokyo transcriptional activation transient responders translational activity University School viral load virus HCV virus RNA Yamaguchi