Animal Experimentation: The Consensus ChangesGill Langley A wide-ranging overview of animal-experimentation. Addresses questions of practice and philosophy, policy and politics in the fast-changing debate about animal use in biomedical research, testing and teaching. |
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Page 77
... dose levels , and comparing them to control animals receiving an uncontaminated diet . The highest dose is normally what has been termed the ' maximum tolerated dose ' ( MTD ) , and the two lower doses are fractions of the MTD . At each ...
... dose levels , and comparing them to control animals receiving an uncontaminated diet . The highest dose is normally what has been termed the ' maximum tolerated dose ' ( MTD ) , and the two lower doses are fractions of the MTD . At each ...
Page 101
... dose ; LD50 signifying the single dose necessary to kill 50 % of test animals ) , results can vary widely between the species , making reliable predic- tions of the human lethal dose impossible . A comparison of the lethal dose of ...
... dose ; LD50 signifying the single dose necessary to kill 50 % of test animals ) , results can vary widely between the species , making reliable predic- tions of the human lethal dose impossible . A comparison of the lethal dose of ...
Page 104
... dosing cannot usually be predicted from a test like the LD50 which uses a single dose . The LD50 of dexamethasone in rats is 120 mg kg ̄1 , but on repeated administration , rats and dogs could not tolerate daily doses above 0.07 mg kg ...
... dosing cannot usually be predicted from a test like the LD50 which uses a single dose . The LD50 of dexamethasone in rats is 120 mg kg ̄1 , but on repeated administration , rats and dogs could not tolerate daily doses above 0.07 mg kg ...
Contents
Are you an animal? | 1 |
Illgotten gains | 19 |
Evidence for pain and suffering in other animals | 42 |
Copyright | |
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Common terms and phrases
ACUCs anaesthesia anaesthetic analgesia animal experimentation animal experiments animal models Animal Procedures Committee animal research animal rights animal studies animal suffering animal tests Animal Welfare animal-welfare animals in research Animals Scientific Procedures assessment behaviour cancer carcinogenicity cats cause cells chemicals clinical cognitive Committee concern culture disease dogs dose drugs effects emotional ensure essay ethical evidence example Fund guinea-pigs Home Office human incompetents important individual inherent value Inspectorate institutions interests involved laboratory animals Lancet LD50 test legislation London medical research Melzack methods mice monkeys motivational-affective nociception nociceptors number of animals pain in animals pain perception patients personal licence potential preference utilitarianism primates problems produce project licence rabbits rats replacement Research Defence Society response rodents scientists social Society species spinothalamic tract subjects techniques teratogenicity thalidomide tissue toxicity testing University utilitarianism Ventricle's vertebrates veterinary vitro vivisection