Mouse Models of Human Cancer
Eric C. Holland
Wiley, Aug 27, 2004 - Science - 482 pages
Mice have become the species of choice for modeling the complexinteractions between tumor cells and the host environment. Mousegenetics are easily manipulated, and a growing array of technologyexists for this purpose. Mouse models allow investigators to betterunderstand causal relationships between specific geneticalterations and tumors, utilize new imaging techniques, and testnovel therapies. Recent developments along these lines show greatpromise for the development of new anti-cancer treatments.
Mouse Models of Human Cancer provides researchersand students with a complete resource on the subject,systematically presenting the principles, methodologies,applications, and challenges associated with this exciting field.Offering a survey of the latest research and a description offuture areas of interest, this text:
From mouse handling and genetic engineering to preclinicaltrials, Mouse Models of Human Cancer is acomprehensive guide to using these models and relating them tohuman disease. Its uniform presentation describes organ-specificmodels in clinical, imaging, and molecular terms, and lays out therelevant genetics, experimental approaches, histologicalcomparisons with human disease, and conclusions.
Combining stellar chapter authors, rich illustrations, andclear, up-to-date coverage, Mouse Models of HumanCancer is an invaluable resource for advanced students andcutting-edge researchers.
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