Mouse Models of Human Cancer

Front Cover
Eric C. Holland
Wiley, Aug 27, 2004 - Science - 482 pages
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Mice have become the species of choice for modeling the complexinteractions between tumor cells and the host environment. Mousegenetics are easily manipulated, and a growing array of technologyexists for this purpose. Mouse models allow investigators to betterunderstand causal relationships between specific geneticalterations and tumors, utilize new imaging techniques, and testnovel therapies. Recent developments along these lines show greatpromise for the development of new anti-cancer treatments.

Mouse Models of Human Cancer provides researchersand students with a complete resource on the subject,systematically presenting the principles, methodologies,applications, and challenges associated with this exciting field.Offering a survey of the latest research and a description offuture areas of interest, this text:

  • Presents real experimental data
  • Describes organ site-specific mouse models
  • Clearly identifies suitable models for further drugtesting
  • Critically analyzes current methodologies and theirlimitations
  • Features numerous recognizable expert contributors
  • Lists key Web sites, reagents, and companies

From mouse handling and genetic engineering to preclinicaltrials, Mouse Models of Human Cancer is acomprehensive guide to using these models and relating them tohuman disease. Its uniform presentation describes organ-specificmodels in clinical, imaging, and molecular terms, and lays out therelevant genetics, experimental approaches, histologicalcomparisons with human disease, and conclusions.

Combining stellar chapter authors, rich illustrations, andclear, up-to-date coverage, Mouse Models of HumanCancer is an invaluable resource for advanced students andcutting-edge researchers.

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About the author (2004)

Eric Holland received his Ph.D. from the University of Chicago in 1985 and M.D. from Stanford University in 1990.  He completed his residency in neurosurgery at UCLA and did postdoctoral work at Stanford and the NIH.  He holds appointments at Memorial Sloan-Kettering Cancer Center and Cornell University.  He is a clinically active neurosurgeon and heads a laboratory at the Sloan-Kettering Institute focused primarily on understanding the molecular mechanisms underlying the pathogenesis of CNS tumors and in modeling these cancers in the mouse. Dr. Holland is the recipient of the Searle Scholars Award, the American Brain Tumor Association Research Award, the Peter Steck Memorial Award, the Bressler Scholars Award and the Seroussi Award.  He has served on the NIH Brain Tumor Process Review Group, is a member of the Mouse Models of Human Cancer Consortium and is the Principal Investigator of the Brain Tumor SPORE program at MSKCC

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