Immunization Safety Review:: Vaccines and Autism

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National Academies Press, Aug 30, 2004 - Medical - 214 pages
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This eighth and final report of the Immunization Safety Review Committee examines the hypothesis that vaccines, specifically the measles-mumps-rubella (MMR) vaccine and thimerosal-containing vaccines, are causally associated with autism. The committee reviewed the extant published and unpublished epidemiological studies regarding causality and studies of potential biologic mechanisms by which these immunizations might cause autism. Immunization Safety Review: Vaccines and Autism finds that the body of epidemiological evidence favors rejection of a causal relationship between thimerosal-containing vaccines and autism. The book further finds that potential biological mechanisms for vaccine-induced autism that have been generated to date are only theoretical. It recommends a public health response that fully supports an array of vaccine safety activities and recommends that available funding for autism research be channeled to the most promising areas. The book makes additional recommendations regarding surveillance and epidemiological research, clinical studies, and communication related to these vaccine safety concerns.

  

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Contents

Vaccines and Autism
21
THE STUDY PROCESS
23
THE FRAMEWORK FOR SCIENTIFIC ASSESSMENT
25
VACCINES AND AUTISM
31
SCIENTIFIC ASSESSMENT
41
SIGNIFICANCE ASSESSMENT
141
RECOMMENDATIONS FOR PUBLIC HEALTH RESPONSE
144
SUMMARY
151
REFERENCES
154
Committee Recommendations and Conclusions from Previous Reports
165
Public Meeting Agenda February 9 2004
180
Thimerosal Content in Licensed Vaccines Adapted from FDA 2003 2004
183
Chronology of Important Events Regarding Vaccine Safety
187
Summary of Public Submissions
192
Acronyms
197
Copyright

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Page viii - Council, he was responsible for making certain that an independent examination of this report was carried out in accordance with institutional procedures and that all review comments were canrt'ulK considered.
Page 19 - M. 2002. A population-based study of measles, mumps, and rubella vaccination and autism.
Page x - The IOM does not propose the use of the criteria it has laid out above in selecting members for federal vaccine advisory committees. The IOM committee was convened for a very different purpose from the usual federal vaccine advisory committees and, as such, required different standards. > As with all reports from the IOM, the committee's work was reviewed by an .*? ^ ">> independent panel of experts. The purpose of the review process is to enhance the clarity, cogency, and accuracy of the...

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