Abnormalities in Puberty: Scientific and Clinical Advances

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Henriette A. Delemarre-Van de Waal
Karger Medical and Scientific Publishers, Jan 1, 2005 - Medical - 181 pages
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Annotation This book on abnormalities in puberty presents an overview on the latest knowledge on the mechanisms of the developmental processes of puberty. Although the exact mechanisms of reawakening of the GnRH pulse generator at the onset of puberty still have to be elucidated, many genetic and environmental factors have been identified to play a major role. Topics discussed in individual chapters include the endocrine and metabolic issues related to the 'developmental origin of adult disease' hypothesis and polycystic ovary syndrome as well as abnormalities in GnRH controlling genes, GnRH-secreting hamartoma as a model for the onset of puberty, experience on the application of GnRH analogues in the treatment of central precocious puberty, and the psychosocial effects of an early puberty. This issue provides the paediatrician, endocrinologist, gynaecologist and general practitioner with underlying information as well as practical tokens on how to manage the various conditions of a disturbed process of puberty.
  

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Contents

Secular Trend of Timing of Puberty
1
Fetal Nutrition and Timing of Puberty
15
Adrenal Function of LowBirthweight Children
34
Puberty and Fertility in Congenital Adrenal Hyperplasia
54
Molecular Genetics of Isolated Hypogonadotropic Hypogonadism and Kallmann Syndrome
67
A ParadigmModel for Studying the Onset of Puberty
81
GonadotropinReleasing Hormone Analogue Treatment for Precocious Puberty
94
Very LongTerm FollowUp of Girls with Early and Late Menarche
126
Polycystic Ovary Syndrome in Adolescence
137
Reversing Sex Steroid Deficiency and Optimizing Skeletal Development in the Adolescent with Gonadal Failure
150
Present and Future Options for the Preservation of Fertility in Female Adolescents with Cancer
166
Author Index
176
Subject Index
177
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