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ability adverse consequences and/or antibiosis aphids application appropriate assessment bacteria biological control agents biological vectors Biotechnology breeders characteristics compatible plants competition concept conducted crop dissemination environment epiphytic establishment evaluating example experimental conditions experimental plot factors field experiments field test frequency gene transfer gene/micro-organism combination genetic material genetically modified micro-organisms genetically modified organisms genetically modified plants GILSP organisms horizontal gene transfer host obligate micro-organisms Industrial Large-Scale Practice insects intended function interaction introduced leafhoppers low-risk organisms mechanical Member countries micro microbial minimise minimum effective inoculum modified micro-organism movement/dispersal nature niche Non-pathogenic non-target organisms occur OECD pathogens plant breeding plant pathogens plants and micro-organisms plasmid pollen population predation production prokaryotes r-DNA organisms Recombinant Recombinant-DNA Safety Considerations reproductive isolation research plot research with genetically research with plants safe selection small-scale field research strains suitable habitats survival and multiplication test micro-organism test plot toxic compound toxins transfer of genetic transport vector system viruses