Complexity in Biological Information ProcessingGregory R. Bock, Jamie A. Goode Many human diseases arise from the malfunction of signalling components, in particular alterations of multiple components of an integrated signalling network. Experimental and computational tools to describe and quantify these changes are increasingly available, providing a wealth of data that can stimulate systematic analysis of the entire signalling network and enable prediction of disease states not easily recognizable from complex data sets. This groundbreaking book explores the structural and temporal complexity in biological signalling exemplified in neuronal, immunological, humoral and genetic signal transduction networks. With discussions between experimentalists and theoretically oriented scientists, this book takes an interdisciplinary approach that may help switch the analysis of biological signalling from descriptive to predictive science and capture the behaviour of entire systems.
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Contents
Terence Sejnowski Introduction | 1 |
Matthias G von Herrath Design of immunebased interventions in autoimmunity | 16 |
diffuse feedback via a diffuse | 31 |
Copyright | |
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action potential firing action potentials aequorin Aertsen amplitude autoimmune behaviour Berridge Biol brain Brenner c-fos CaČ Ca2+ signalling Ca2+ spike calcium calmodulin CaMKII cascade cell types cellular channels coding fraction Complexity in biological cortex CREB cytokines cytoplasm dendrite dependent Diesmann direction selectivity Dolmetsch dynamics encoding EPSP ERK activation example excitatory neurons expression patterns feedback frequency function gene expression genome GPCR growth factor Hebbian learning hormone hybridization images immune system information processing inhibition inhibitory input InsP3 interactions interneurons intracellular Ca2+ Iyengar kinetics Laughlin learning MAP kinase MAPK mechanisms membrane mitochondria model neuron modulation molecular molecules mouse neural neuron N1 neurons Neurosci Novartis phosphorylation photoreceptors physiological postsynaptic predict presynaptic protein kinase pulse Rap1 receptor regulation response role RTKs second messenger Segel Sejnowski sequence signal transduction signalling pathways specific spike train stimulus synapses synaptic plasticity synchronization temporal coding tissue transcription transients tyrosine kinase visual