Signaling Pathways in Liver Diseases (Google eBook)
Jean-François Dufour (M.D.), Pierre-Alain Clavien
Springer, Dec 1, 2009 - Medical - 586 pages
Signaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations and how they can be influenced. Better comprehension of the cellular mechanisms participating in liver regeneration, hepato-cellular apoptosis and ischemia/reperfusion inquiry is mirrored by a dramatic increase in complexity. The number and scope of publications is intimidating and difficult for busy individuals to extract a coherent framework. This book will serve as a source of information facilitating the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets for novel therapeutic strategies. It will furthermore stimulate more research and lead to better exchange between the laboratory, the clinical ward and the operation room.
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AMPK apoptosis b-catenin bile acid biliary binding Biochem Biol Chem c-Jun Ca2+ calcium Cancer caspase cell death cellular cholangiocytes chronic hepatitis cirrhosis complex cytokines domain effects endothelial cells endothelial growth factor enzymes function Gastroenterology gene expression glucose hepatic stellate cells hepatitis B virus hepatocellular carcinoma hepatocytes Hepatol Hepatology HSEC human hypoxia immune Immunol increased induced infection inhibition inhibitor insulin resistance interaction intracellular involved isoforms Kupffer cells ligands lipid liver disease liver injury liver regeneration mechanisms mediated membrane metabolism mice miRNA mitochondrial modulate molecules mouse mRNA mTOR mutations Natl Acad Sci NF-kB NKT cells nuclear receptor oxidative patients phosphorylation Physiol platelets PPARa Proc Natl Acad proliferation promote protein kinase regulation response role signaling pathways sinusoidal stimulation stress synthesis T-cells target genes tion tissue transcription factors tyrosine upregulation vascular endothelial growth VEGF viral vivo