Stem Cell Therapy for Diabetes (Google eBook)
Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes.
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Acad Sci USA acinar cells activation activin adult human alemtuzumab allograft apoptosis Beta Cells Beta-cell Bonner-Weir cell cycle cell differentiation cell types clinical culture cyclin Dev Biol Diabetologia dorsal duct cells ductal ECM scaffold effects embryonic stem cells encapsulated endocrine cells Endocrinol endoderm epithelial epithelium exocrine pancreas ﬁndings ﬁrst foregut function gene expression glucagon glucose growth factor hepatocyte HES1 human islets human pancreatic hyperglycemia immune immunosuppression induced insulin insulin secretion insulin-positive insulin-producing cells islet cells islet graft islet transplantation kidney lineage liver cells markers mesenchyme metabolic microcapsules molecules mutant Natl Acad Sci neogenesis NGN3 NOD mice normal NOTCH signaling pancreas development pancreas transplantation pancreatic cells pancreatic islets pathway patients PDX1 phenotype Proc Natl Acad progenitor cells proliferation protein protocol receptor recipients regeneration regulation replication reprogramming rodent role signiﬁcant speciﬁc SPK transplant studies T1DM therapy tissue transcription factor transdifferentiation transgenic type 1 diabetes vitro vivo