Genetic Disorders of the Indian Subcontinent

Front Cover
Dhavendra Kumar
Springer Science & Business Media, Oct 20, 2004 - Medical - 608 pages
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The Indian subcontinent is a vast land mass inhabited by over one billion people. Its rich and varied history is reflected by its numerous racial and ethnic groups and its distinct religious, cultural and social characteristics. Like many developing countries in Asia, it is passing through both demographic and epidemiological transitions whereby, at least in some parts, the diseases of severe poverty are being replaced by those of Westemisation; obesity, diabetes, and heart disease, for example. Indeed, as we move into the new millennium India has become a land of opposites; on the one hand there is still extensive poverty yet, on the other hand, some of the most remarkable developments in commerce and technology in Asia are taking place, notably in the fields of information technology and biotechnology. India has always fascinated human geneticists and a considerable amount of work has been done towards tracing the origins of its different ethnic groups. In the current excitement generated by the human genome project and the molecular and genetic approach to the study of human disease, there is little doubt that this field will develop and flourish in India in the future. Although so far there are limited data about genetic diseases in India, enough is known already to suggest that this will be an extremely fruitful area of research.
  

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Contents

The Indian subcontinent and human genetics An introduction
1
Ethnic and cultural diversity
29
Genomic and gene diversity among the people of the indian subcontinent
57
Epidemiology of genetic diseases
81
Immunogenetic basis of variation and disease susceptibility
89
Consanguinity cultural religious and social aspects
125
Congenital developmental anomalies
137
Malformation syndromes in India
155
Inherited skeletal dysplasias and collagen diseases
313
Deafness and related syndromes
347
Genetics diseases of the eye in India
369
The genetics of cancer the Indian subcontinent perspective
399
Diabetes mellitus and related disorders
413
Coronary heart disease and related diseases
447
Diseases of the kidney clinical spectrum and genetics
467
The genetics of resistance to malaria
479

Down syndrome in India
167
Inherited metabolic diseases among South Asians in the United Kingdom
181
Management of inherited metabolic diseases in India
207
Indian childhood cirrhosis and other metabolic liver diseases
223
Thalassaemias and other haemoglobinopathies
245
Disorders of haemostasis and thrombosis
265
Glucose6phosphatedehydrogenase deficiency and other inherited red cell defects
275
Genetic neurological and psychiatric diseases
291
Genetic disorders and medical genetics in India
501
Genetic disorders and medical genetics in Sri Lanka
519
Genetic counselling for families from the Indian subcontinent
541
Ethical issues in clinical genetics and the Indian subcontinent
555
Glossary
573
Index
579
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