Genetic Disorders of the Indian Subcontinent

Front Cover
Dhavendra Kumar
Springer Science & Business Media, Oct 20, 2004 - Medical - 608 pages
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The Indian subcontinent is a vast land mass inhabited by over one billion people. Its rich and varied history is reflected by its numerous racial and ethnic groups and its distinct religious, cultural and social characteristics. Like many developing countries in Asia, it is passing through both demographic and epidemiological transitions whereby, at least in some parts, the diseases of severe poverty are being replaced by those of Westemisation; obesity, diabetes, and heart disease, for example. Indeed, as we move into the new millennium India has become a land of opposites; on the one hand there is still extensive poverty yet, on the other hand, some of the most remarkable developments in commerce and technology in Asia are taking place, notably in the fields of information technology and biotechnology. India has always fascinated human geneticists and a considerable amount of work has been done towards tracing the origins of its different ethnic groups. In the current excitement generated by the human genome project and the molecular and genetic approach to the study of human disease, there is little doubt that this field will develop and flourish in India in the future. Although so far there are limited data about genetic diseases in India, enough is known already to suggest that this will be an extremely fruitful area of research.
  

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Contents

The Indian subcontinent and human genetics An introduction
xvii
Ethnic and cultural diversity
27
Genomic and gene diversity among the people of the indian subcontinent
55
Epidemiology of genetic diseases
79
Immunogenetic basis of variation and disease susceptibility
87
Consanguinity cultural religious and social aspects
123
Congenital developmental anomalies
135
Malformation syndromes in India
153
Inherited skeletal dysplasias and collagen diseases
311
Deafness and related syndromes
345
Genetics diseases of the eye in India
367
The genetics of cancer the Indian subcontinent perspective
397
Diabetes mellitus and related disorders
411
Coronary heart disease and related diseases
445
Diseases of the kidney clinical spectrum and genetics
465
The genetics of resistance to malaria
477

Down syndrome in India
165
Inherited metabolic diseases among South Asians in the United Kingdom
179
Management of inherited metabolic diseases in India
205
Indian childhood cirrhosis and other metabolic liver diseases
221
Thalassaemias and other haemoglobinopathies
243
Disorders of haemostasis and thrombosis
263
Glucose6phosphatedehydrogenase deficiency and other inherited red cell defects
273
Genetic neurological and psychiatric diseases
289
Genetic disorders and medical genetics in India
499
Genetic disorders and medical genetics in Sri Lanka
517
Genetic counselling for families from the Indian subcontinent
539
Ethical issues in clinical genetics and the Indian subcontinent
553
Glossary
571
Index
577
Copyright

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