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acid activity adjuvant agglutination allogeneic amino-acid anaphylaxis animals anti antibody antibody molecules antibody production antigen antigen and antibody antigen-antibody antilymphocyte serum antisera antiserum bacterial Biol blood blood-group substances cell-mediated cellular chemical competent cells complement complex components cross-reactions culture cytotoxic delayed hyper delayed hypersensitivity detected determinants donor dose effect enzymes erythrocytes evidence experimental factors gamma-globulin genetic globulin glycolipids graft guinea-pigs haemolytic hapten heavy chains heterologous homograft homologous host human immune response immunoglobulins induced inhibition injection irradiation isogenic Landsteiner leucocytes light chains lymph-node lymphocytes lymphoid cells lysis macrophages mechanism mice molecular mouse non-specific normal passive phagocytosis Phytohaemagglutinin plasma cells polysaccharide precipitation present primary protein rabbit react reactivity red cells red-cell result role sensitized sera serological serum skin soluble specific antigen spleen spleen cells stimulation strain structure Studies thymectomy thymus thyroid tion tissue tolerance transfer transformation transplantation tuberculin tumour virus vitro