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0-endorphin Acad Sci ACTH ACTH release ACTH secretion action activity administration adrenal aldosterone amino acids angiotensin animals antibodies atrial natriuretic factor atrial natriuretic peptide basal binding sites biological blood blood-brain barrier Brain Res Brattleboro catecholamines central cerebral circulating Clin Endocrinol concentrations corticosterone cortisol decreased denotes diabetes dopamine dopaminergic dose effects elevated Endocrine Endocrinology endogenous endothelial cells exam Figure fluid function glucocorticoid receptor hippocampus human hypertension hypothalamic immune increased plasma induced infusion inhibin injection interleukin-1 Kastin Kvetnansky male rats mechanisms median eminence Metab microvessels mineralocorticoid receptors modulation nervous system neuroendocrine Neuroendocrinology neurons Neurosci normal oxytocin paraventricular nucleus perfusion peripheral permeability Physiol physiological pituitary cells plasma plasma levels plasma NE levels prolactin protein rat brain regulation renal renin response role saline serotonin serum significantly sodium somatostatin stimulation stress stress-induced studies substances sympathetic tissue transport uptake vasopressin vitro vivo