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adeno adenovirus antibody antigen Bethesda Burkitt lymphoma Cancer Research Fund cell DNA cell lines cells infected cells transformed cleavage clones Cold Spring Harbor complementation groups contain cytoplasmic daltons deletion Department of Microbiology detected DNA molecules DNA replication DNA sequences DNA synthesis early embryo cells endogenous enzyme fraction fragments gene genetic genome herpes simplex virus human hybridization Imperial Cancer Research infected cells integration isolated labeled late leukemia lymphocytes lymphoma lytic infection mammalian Maryland mice Molecular Biology molecular weight mRNA murine mutants mutants of SV40 nuclear particles polyoma DNA polypeptides proteins provirus purified recombination restriction endonuclease restrictive temperature RNA tumor viruses RNA-directed DNA polymerase Rous sarcoma virus School of Medicine sedimentation specific Spring Harbor Laboratory strains strand structure studies subunits SV40 DNA SV40 genome SV4O tion transcripts transformed cells type-C viral DNA replication viral genome virions Virology virus DNA virus-specific vitro wild type