Cigarette smoking and the kidney
There is considerable evidence suggesting that chronic cigarette smoking has adverse health effects: it is the major cause of disease and death in developed countries, inducing several kinds of cancer, chronic obstructive lung disease and severe vascular pathologies.Cigarette smoking is also a risk factor for diffuse atherosclerosis, ischemic heart disease and peripheral vascular lesions, renal microvessels being another potential target. Furthermore, the relationships of chronic cigarette smoking and nitric oxide with endothelial dysfunction and vascular disease are well proven, and the association between eNOS gene polymorphisms and vascular disease and their dependence on chronic tobacco smoking has been stressed. But although there is definite evidence that the risk of progression of acquired or genetic renal disease is higher in chronic cigarette smokers and the negative effect on patient survival in chronic dialytic treatment is well known, these issues are still neglected by clinical nephrologists and the mechanisms involved have not yet been classified.It is for these reasons that the present volume has been put together: the questions addressed will be of particular interest to renal researchers working on an experimental basis as well as for oncologists and toxicologists.
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Smoking and Health with a Note on Kidney Cancer
Effects of Cigarette Smoking on Systemic Hemodynamics
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ACE inhibitor activity albuminuria anti-GBM disease associated atherosclerosis basement membrane Battini G eds blood pressure cancer case-control cGMP chronic cigarette smokers chronic renal cigarette smoking Circulation Clin clinical Contrib Nephrol current smokers diabetes mellitus diabetic nephropathy diabetic patients dysfunction Effect of cigarette effects of smoking endothelial cells endothelial nitric oxide endothelium Engl ESRF ex-smokers Gambaro G glomerular filtration rate glomerulonephritis Goodpasture's syndrome HD patients healthy controls hypertension IgAN patients increased induced inhibition insulin ischemic Japanese Karger Kidney Int levels lung male Meroni microalbuminuria myocardial nephritis Nephrol Dial Transplant nicotine nitric oxide synthase nonelderly nonsmokers odds ratio oxide synthase gene patients with diabetes patients with type peripheral plasma population prevalence primary renal disease proteinuria pulmonary rare allele renal function renal hemodynamics Ritz role Schrier RW Sessa significant smoking on renal Soc Nephrol subjects superoxide sympathetic syndrome tobacco smoke type 2 diabetes urine vascular disease vasoconstriction