Neuropsychology of HIV Infection, Issue 494

Front Cover
Igor Grant, Alex Martin
Oxford University Press, 1994 - Medical - 385 pages
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The human immunodeficiency virus (HIV) commonly enters the central nervous system, disturbs brain function, and ultimately results in serious brain damage. The most dangerous manifestation of this infection of the brain is HIV-associated dementia, which includes extreme memory loss, slowness in thinking, disorientation, and social incapacity. Most persons who are HIV-infected do not develop severe dementia; however, perhaps 50% of those with AIDS and a smaller proportion of HIV-infected carriers suffer from more subtle brain disorders that can be revealed by proper neuropsychological testing. This ground-breaking volume is the first to summarize the current state of knowledge about the neurocognitive disorders associated with HIV-1 infection. With contributions from leading authorities in the field, the book fully discusses the prevalence, qualitative features, natural course, and effects of neuropsychological impairments in persons with HIV infection. Neuropsychological data are related to findings from studies of brain imaging, neuropathology, and the effects of antiretroviral treatments. This critical work will be essential for neuropsychologists, infectious disease physicians, neurologists, and all those involved in AIDS research and treatment.
  

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Contents

INTRODUCTION
3
CNSImmune Interactions
41
Neurological and Neuropathological Manifestations of HIV Infection
56
Structural Brain Imaging of HIV Infection
108
Methodological and Conceptual Issues in the Study of Cognitive Change
146
Individuals
161
Development of a Screening Battery for HIVRelated Cognitive
176
The Utility of Clinical Ratings for Detecting Cognitive Change in
188
HIV Cognition and the Basal Ganglia
234
Neuropsychological and Pathological
260
Neuropsychological Response to Antiretroviral Therapy in
276
A Clinical Perspective
295
Developmental Deficits and Behavioral Change in Pediatric AIDS
310
Motor and Cognitive Functioning in Nonhuman Primates Infected with
339
EPILOGUE
359
Index
367

Everyday Functioning and Its Relationship to Cognitive Impairment
207
Neuropsychological Assessment of Seropositive Intravenous Drug
220

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About the author (1994)

Igor Grant is at Veterans Affairs Medical Center, San Diego. Alex Martin is at National Institute of Mental Health.

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