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abnormal acid adequate margin afford an adequate alcohol consumption animals anomalies anticonvulsant appears to afford associated birth defects birth weight born to mothers caffeine Chasnoff chemicals child cigarette smoking Clin clinical cocaine coffee congenital defects congenital malformations congenital rubella syndrome consumption during pregnancy Current TLV appears cytomegalovirus developmental diagnostic disease dose drinking drugs embryo embryopathy environmental epidemiological ethanol fetal alcohol syndrome Fetotoxic fetus genetic gestation growth retardation hazards Health herpes simplex virus human immunodeficiency virus incidence increased infants born infection inhalation intrauterine isotretinoin levels margin of safety maternal smoking maternally toxic concentrations mental retardation mercury metabolism microcephaly neonatal newborn nicotine Obstet Gynecol offspring outcome parents Pediatr percent perinatal Persaud physician placental pregnancy pregnant women prenatal prospective study radiation rats reported safety Current TLV spontaneous abortion teratogenesis teratogenic teratogenic effects Teratology thalidomide tion Toxicol trimester utero utero exposure varicella warfarin workplace