Leukemias: Principles and Practice of Therapy (Google eBook)

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Stefan Faderl, Hagop Kantarjian
John Wiley & Sons, Sep 14, 2011 - Medical - 456 pages
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Edited by experts from one of the world’s largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatments present an outlook for the future and explain the rationale for ongoing clinical trials.

Topics include:

  • Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, kit inhibitors, BCR-ABL inhibitors)
  • Ras inhibitors
  • Epigenetic therapy (hypomethylaters and histone deacetylase inhibitors)
  • Lenalidomide analogs
  • New chemotherapy drugs, e.g. clofarabine, cloretazine, sapacitabine, forodesine
  • Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols in combination with dasatinib or imatinib)
  • New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40)
  • Thrombopoietic agents

Leukemias: Principles and Practice of Therapy

  • Includes practical information to guide you in challenging situations, such as treatment of elderly patients, pregnancy, relapsed and refractory disease
  • Incorporates chapters on supportive care and pharmacologic information about the most frequently used drugs in this area
  

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Contents

10 Induction Therapy of Acute Myeloid Leukemia
125
Background and Diagnostic 1 Keith W Pratz and Judith E Karp
148
Traditional Diagnostic Approaches 29 13 The Pathophysiology of Acute Promyelocytic
163
New Diagnostic 14 Acute Promyelocytic Leukemia Manifestations
169
Presentation
183
Myelodysplastic Syndromes 77 Diagnosis and Classification 183 Sandeep Gurbuxani and John Anastasi
193
Classification and Risk Assignment 87 Leukemia
217
Myelodysplastic Syndromes 99 18 Philadelphia Chromosomepositive Acute
228
Pathophysiology
299
The Role of Stemcell Transplantation in Chronic
315
Management of Elderly Patients
327
Hairy Cell Leukemia
341
Therapeutic Approaches to the Mature Tcell
348
Philadelphia Chromosomenegative
362
Management of Emergencies in Leukemias
375
Management of Infectious Complications
392

Acute Myeloid Leukemia 115 19 Acute Lymphoblastic Leukemia in Adolescents
244
Novel Molecular Michael E Rytting
250
Pathophysiology of Chronic Myeloid
261
Therapy of Newly Diagnosed and Chronicphase
271
Therapy of Advancedstage and Resistant Chronic
281
Transfusion Support and Hematopoietic Growth
411
Acute Myeloid
419
Index
429
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