Hormonal Control of LactationResearch on the hormonal control oflactation - the subject of this monograph - has long been the major interest of this laboratory. Studies were initiated in the mid 1930s by the late Professor S. 1. Folley, FRS, who directed the work with immense enthusiasm and devotion until his untimely death in 1970. This fruitful area of basic and applied research has, in recent years, attracted widespread attention; there have been many exciting events and developments with a dramatic increase in the number of publications. These events are diverse and include the identification, isolation and sequencing of human prolactin; the identification and isolation of placentallactogens in several ruminant species with recognition of their importance in mammary growth and differentiation; the introduction of highly sensitive bioassay, radioimmuno- and radioreceptor-assay techniques for mammotrophic hormones; the growing clinical appreciation of the immunological and nutritional importance of colostrum and milk to the newborn; the intensification of studies on normal mammogenesis to establish a sound basis for studies on mammary cancer; and the exploitation of the mammary gland, with its characteristic differentiation patterns and multiple synthetic abilities, as a valuable tissue for the investigation of basic mechanisms involved in the synthesis under hormonal control of enzymes and secretory proteins; and for the study of hormone - receptor interactions. |
Other editions - View all
Common terms and phrases
acid Acta Endocrinol alveoli animals assay basal bio-assay Biochem Biol biological activity blood bovine casein circulating colostrum concentrations corticosteroids cortisol cows Dairy Sci ducts effect Endocrinology Fert fetal Folley Forsyth Friesen gestation glucocorticoids goats growth hormone Hart human GH human placental lactogen increase induced inhibition injection insulin iodinated lactating rat lactogenesis lactose Linzell lobulo-alveolar luteinizing hormone mammary development mammary gland mammary growth mammary tissue membrane messenger RNA metabolism mice milk ejection milk secretion milk yield mouse mammary gland ng/ml plasma normal oestradiol oestradiol-17ẞ oestrogen oestrous cycle oestrus ovariectomized ovariectomy ovine prolactin ovulation oxytocin parturition Peaker peripheral plasma pg/ml physiological pituitary pregnancy Proc prolactin and GH prolactin binding prolactin levels prolactin receptors prolactin release prolactin secretion protein pseudopregnant rabbit radioimmunoassay rat mammary gland receptors Reprod response role ruminants Schams secretory Sect serum sheep species steroids stimulation studies suckling synthesis teat udder vitro