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adenocarcinoma adjuvant ampulla of Vater anastomosis Ann Surg artery atic cancer Beger bile duct biliary Buchler Cameron JL cancer cells Cancer Res chemotherapy chronic pancreatitis Clin clinical creatic cancer cystadenoma cystic neoplasms cystic tumors detection diabetes diagnosis of pancreatic disease distal ductal adenocarcinoma endocrine tumors endoscopic ERCP evaluation exocrine fistula gastric gastrinomas Gastroenterol gastrointestinal gemcitabine gene genetic growth factor hepatic histological Hospital Hruban RH imaging intraductal invasion islet cell jaundice K-ras K-ras mutations laparoscopy lesions liver lymph nodes malignant metastases mortality mucinous cystic obstruction octreotide Oncol operation pain palliation pancre pancreatectomy pancreatic adenocarcinoma pancreatic cancer pancreatic carcinoma pancreatic duct pancreatic head pancreatic resection pancreatic tumors pancreaticoduodenectomy Pancreatol Pathol patients with pancreatic periampullary portal vein postoperative preoperative procedure prognosis radical receptor reported resection serous somatostatin staging stent surgeon surgical symptoms therapy tients tion tissue tive tomy total pancreatectomy tumor markers unresectable Whipple Yeo CJ