Polyfunctional cytokines: IL-6 and LIF., Volume 167
Experts from a variety of areas compare and discuss IL-6 and LIF in order to provide a new understanding of their modes of action, the significance of their polyfunctionalization--why the body chooses to use one molecule to regulate various cell types--and their functional overlap. Covers such topics as actions of IL-6 and LIF on lymphoid populations, on megakaryocyte and platelet production, on bone metabolism, their effects on leukemic cells and much more. Includes contributions from researchers working on a variety of cell types and organ systems along with potential clinical applications regarding these two factors.
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j N M Gough T A Willson J Stahl and M A Brown Molecular
S Aldra H Isshild T Nakajima S Kinoshita Y Nishio S Natsuka
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Aarden Acad Sci USA activity acute-phase protein acute-phase response affinity receptors amino acids amniotic fluid antibody apoptosis assay Baumann binding biological bone marrow C/EBP CDF/LIF cDNA cell lines cell types clone colony-stimulating factor complex culture detected dexamethasone differentiation effects of IL-6 embryonic expression function G-CSF Gauldie Gough growth factor haemopoietic hepatocytes high affinity Hirano human IL-6 IL-6 and LIF IL-6 gene IL-6 receptor Immunol increase induced inhibition injected interleukin Kishimoto leukemia inhibitory factor levels LIF gene LIF receptor ligand liver Lotem low affinity macrophages megakaryocyte Metcalf Ml cells molecular molecule monocytes mRNA murine myeloid myeloid leukaemic cells myeloma Natl Acad Sci neurons Nicola normal Oncostatin osteoblasts patients plasma cells plasmacytoma platelet preterm Proc Natl Acad production progenitor proliferation promoter recombinant region regulation resorption Romero Sehgal sequence serum signal soluble stem cells stimulation subunit tissues transcription factor transducer transfected tumour necrosis factor vitro vivo