Cardiovascular DrugsJames A. Bristol A comprehensive treatment of the chemistry, biochemistry, pharmacology, and test methodology of drugs used to treat the major cardiac diseases. Outlines the basic aspects of cardiac dysfunction, giving an analysis of some common threads linking cardiac disease states. Provides specific information on screening methodology, including in vitro and whole animal models; extensive coverage of drug classes, including beta-adrenoceptor antagonists, calcium antagonists, antianginals, cardiotonic agents, and antiarrhythmic agents, and new cardiovascular drugs; and an analysis of the state of therapy for cardiac dysfunction and future directions for research and development. |
Contents
INITIATING | 1 |
SCREENING METHODS AND TEST MODELS FOR | 41 |
BADRENORECEPTOR ANTAGONISTS | 101 |
Copyright | |
6 other sections not shown
Common terms and phrases
acid action potential action potential duration adenosine agonist alinidine alkyl amiodarone amrinone anesthetized angina antianginal antiarrhythmic activity antiarrhythmic agents antiarrhythmic drugs antihypertensive Arzneim atrial blood flow blood pressure Ca2+ calcium calcium antagonists cardiac arrhythmias cardiac cells cardiac output Cardiol Cardiovasc cardiovascular channel Chem Circ Circulation Clin clinical compounds concentrations contractility coronary artery decrease depolarization diltiazem disopyramide dobutamine dogs dose effects electrophysiological evaluation Forsch./Drug Res gallopamil half-life heart failure heart rate hemodynamic hypertension increase inhibition inotropic intracellular intravenous ischemic isoproterenol lidocaine lorcainide mechanism membrane metabolism metabolites mg/kg myocardial infarction myocardial ischemia myocardium nifedipine nitroglycerin occlusion oral oxygen patients Pharmacol pharmacological Physiol plasma positive inotropic prenalterol procainamide produced pronetalol propranolol quinidine rats receptor reduced refractory period response sodium ẞ-blockers stimulation Structure-Activity Relationships studies substituents sulmazole synthesis tachycardia Ther therapeutic therapy tissue trapidil treatment vascular smooth muscle vasodilator ventricular fibrillation verapamil vitro