Cell Commitment and Differentiation

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CUP Archive, 1987 - Science - 244 pages
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First published in 1987, this book is about how cells differentiate; that is it describes the way in which cells in animal and plant bodies take on their specialised fates. It has long been recognised that since all such cells retain copies of all genes, the genetic explanation for tissue differences lies in the controlled expression of restricted sets of genes. But how is the choice made and how are such restricted groups of genes activated and regulated? This book discusses these questions and describes both determination and differentiation. The mechanisms that underlie the processes are described for the embryo and in the adult. Determination may occur in adult life during regeneration, wound healing, cancer formation and in the immune and blood systems, and the possible genetic basis for the events is explored. The influence of the cell environment, the cell surface and the pericellular-extracellular matrix as mediators of external signals is discussed.
  

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Page 228 - A repressor (MATa2 product) and its operator control expression of a set of cell type specific genes in yeast. Cell 42, 237-247.
Page 224 - Early, P., Rogers, J., Davis, M., Caíame, К., Bond, M., Wall, R., and Hood, L. (1980). Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways.
Page 231 - Morphological observations of prostatic induction by urogenital sinus mesenchyme in epithelium of the adult rodent urinary bladder. J. Cell Bio/., 96, 1662-70 16.
Page 224 - Bolton, VN (1982). The transition from maternal to embryonic control in the 2-cell mouse embryo. EMBO J.
Page 225 - RG 1982. Investigation of cell lineage and differentiation in the extraembryonic endoderm of the mouse embryo. J. Embryol. Exp.
Page 236 - Scharff. 1981. Monoclonal antibodies: A powerful new tool in biology and medicine. Ann. Rev. Biochem.
Page 223 - Epithelial-mesenchymal interactions in prostatic development. I. Morphological observations of prostatic induction by urogenital sinus mesenchyme in epithelium of the adult rodent urinary bladder. J CELL BIOL 96 ; 16621670.
Page 226 - K. and Takeichi, M. (1986). Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development. Nature, 320: 447-449.

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About the author (1987)

Hall went to Dalhousie University, Halifax, Nova Scotia, Canada.

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