Neuroglia

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Helmut Kettenmann, Bruce R. Ransom
Oxford University Press, 2005 - Medical - 601 pages
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Neuroglia is the only comprehensive reference book on the basic biology and function of glial cells. This long-awaited second edition has been completely reorganized and rewritten to include the dramatic advances in this field since the first edition was published ten years ago. The impact of the second edition will be greater than that of the first because the majority of neuroscientists now acknowledge that neuroglia are elemental to most, if not all, brain functions. The second edition covers the entire field of glial research from the basic molecular and cellular principles of these cells to their involvement in neurological diseases including stroke, Alzheimer's disease, and multiple sclerosis. It includes new chapters on transmitter release from exocytosis from glia, glia derived stem cells, glia and synaptic transmission, glia and axon guidance, an entirely new section on mechanisms of glial injury, and several new chapters on the roles of glia in different diseases. The new edition was written with both students and experts in mind. It provides a basic introduction to the entire range of glial topics and detailed information with critical assessment of the research literature. Neuroscience textbooks focus on the properties of neurons, whereas this book fills the information void about the brain's other cells. Neuroglia, Second Edition, is an essential reference source for newcomers, including graduate students, to neuroanatomy, neurochemistry, neurophysiology, and molecular neurobiology. It is also a vital companion for established researchers in these fields as well as clinicians in neurology, neurosurgery, psychiatry, neuropathology, and neuro-oncology.
  

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Contents

Astrocytes and ependymal glia
19
Structure and function of oligodendrocytes
36
Schwann cells and myelin
48
Microglial cells
60
Lineages of astrocyles and oligodendrocytes
72
The Schwann cell lineage
85
The role of neurogenic astroglial cells in the developing and adult central nervous system
101
Voltageactivated ion channels in glial cells
112
Extracellular potassium and pH homeostasis and signaling
334
Astrocyte neurotransmitter uptake
346
Glia and synoptic transmission
355
The central role of astrocytes in neuroenergetics
367
Growth factors for neurons provided by macroglial cells
377
Radial glial cells scaffolding for cortical development and evolution
389
Axon guidance
405
Astrocyte injury
421

Receptors for neurotransmitters and hormones
131
Cytokine and chemokine receptors and signaling
146
Mechanisms of solute transport in glia
163
Gap junctions and hemichannels
177
Quanta release of transmitter not only from neurons but from astrocytes as well?
190
Enzymes of carbohydrate and energy metabolism
202
Second messenger systems
216
Intracellular calcium control mechanisms in glia
229
Cytoskeletal proteins in astroglia
240
Molecular biology of myelination
253
Factors controlling myelin formation
264
Myelin function and saltatory conduction
273
Cytokine production
285
Interaction of glial cells with monocytes
302
Antigen processing presentation and T cell interaction
314
The role of glia in the formation and function of the bloodbrain barrier
325
Oligodendrocyte and Schwann cell injury
430
Response of microglia to brain injury
443
Axonal regeneration in the peripheral nervous system of mammals
454
Axonal regeneration in the central nervous system of mammals
467
Transplantation of myelinforming cells
477
Multiple sclerosis
489
Human immunodeficiency virus infection of the central nervous system
501
Focal cerebral ischemia The multifaceted role of glial cells
511
Gliomas
521
Neurological mouse mutants a moleculargenetic analysis of myelin proteins
532
Astrocytic swelling in neuropathology
550
The activation of microglia as an early sign of disease progression in Alzheimers disease
563
Peripheral neuropathy and the Schwann cell
573
Reaction of glial cells in infectious disorders of the central nervous system
586
Index
593
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About the author (2005)

Helmut Kettenmann is at Max-Delbruck Center for Molecular Medicine, Berlin. Bruce R. Ransom is at University of Washington.

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