Depression: a psychobiological synthesis
Presents a comprehensive review of empirical evidence for changes in the brain that are responsible for depression, including recent research on the functions of identified neural pathways. Discusses the psychology of depression and evaluates current theories on the topic. Develops an inclusive theory of depression that encompasses many existing theories and clarifies their interrelationships.
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On the Nature of Psychobiological Explanations
What Do We Mean by Depression?
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5-HT function 5-HT receptor 5-HT turnover 5-HT uptake abnormal activity administration affective disorders agonist alpha-receptor amitriptyline amphetamine analgesia animal models anticholinergic antidepressant drugs antidepressant effects antidepressant treatment autoreceptor behavioral beta-receptors biochemical brain catecholamine cells central changes Chapter chlorimipramine cholinergic chronic antidepressant chronic treatment clinical clonidine co-workers cortex decrease depres depressed mood depressed patients dorsal bundle doses effects of antidepressants endogenous depression enhanced evidence forebrain frontal GABA Goodwin hormone hypothesis imipramine increase induced inhibition inhibitor iprindole learned helplessness lesions levels locus coeruleus low 5-HT MAOIs mechanisms mediated MHPG excretion mianserin models of depression muricide neuroleptic neurons neurotransmitter normal nucleus nucleus accumbens number of studies observed opiate pathways Pharmacol pharmacological physiological plasma platelet postsynaptic potential presynaptic prolactin Psychiatr Psychol psychomotor raphe rats reduced release REM sleep reported reserpine response reward Section shock stimulation stress suggest suppression symptoms synthesis transmission tricyclic antidepressants tryptophan unipolar validity zimelidine