Xenotransplantation

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Daniel R. Salomon, Carolyn Wilson, Carolyn Anne Wilson
Springer Science & Business Media, Jul 23, 2003 - Medical - 257 pages
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Xenotransplantation could have an impact on at least three aspects of medicine. The first is as a means of overcoming a severe shortage of human donor organs for the treatment of organ failure. The second aspect relates to the possibility that a xenogeneic organ would not be susceptible to infection by a "human" virus and thus the xenograft might resist injury caused by such viruses. The third and, as of yet, unexplored aspect relates to a means of delivering genes for therapeutic purposes thus overcoming some of the limitations of "conventional" gene therapy.     

  

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Contents

Genetic Modification of Xenografts
1
Public Health Risks Patient vs Society in an Emerging Field
23
R A WEISS
47
G MICHAELS
73
Understanding Xenotransplantation Risks from NonHuman Primate
101
Exogenous Porcine Viruses
125
CrossSpecies Infection and Risk
185
Molecular Cloning and Functional Characterization of Infectious
217
Xenotransplantation Federal Regulatory Considerations
239
Subject Index
253
Copyright

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About the author (2003)

The daughter of Harry Leon Wilson, a popular novelist of the 1920s, Charis Wilson was born in San Francisco on May 5, 1914, and grew up in Carmel. There she met Edward Weston in 1934 and offered to pose for him. For the next ten years, she was Weston's model-- posing for approximately half of all his recorded nudes-- as well as his lover (they were married in 1939). In 1936 Wilson urged Weston to apply for a Guggenheim fellowship, took his original four-line application and turned it into four pages, and helped him become the first photographer ever to win the award. Wilson described the Guggenheim travels in "California and the West, published in 1940.
Edward Weston was born March 24, 1886, in Highland Park, Illinois. He made his first photographs in 1902 with a Kodak Bull's Eye #2 camera-- a gift from his father. In 1911, five years after moving to California, he opened his own portrait studio in Tropico (now Glendale), California, and began to earn an international reputation for his work. But it was not until 1922 that he came fully into his own as an artist, with his photographs of the Armco Steel mill in Ohio. During 1923-26 he worked in Mexico and in California, where he lived with his sons, Chandler, Brett, Neil, and Cole. Though he continued to support himself with portrait work, Weston turned increasingly to subjects of his own choosing, such as nudes, clouds, and close-ups of rocks, trees, vegetables, and shells. During 1937-39, on a Guggenheim Fellowship, he traveled and photographed throughout the American West. Three years later, he toured the South and East, taking photographs for a limited edition of Whitman's "Leaves of Grass, until the attack on Pearl Harbor cutshort his journey. In 1948 Weston made his last photograph; he had been stricken with Parkinson's disease several years earlier. On January 1, 1958, he died at Wildcat Hill, his home in Carmel, California.

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