XenotransplantationCarolyn Wilson, Daniel R. Salomon Xenotransplantation could have an impact on at least three aspects of medicine. The first is as a means of overcoming a severe shortage of human donor organs for the treatment of organ failure. The second aspect relates to the possibility that a xenogeneic organ would not be susceptible to infection by a "human" virus and thus the xenograft might resist injury caused by such viruses. The third and, as of yet, unexplored aspect relates to a means of delivering genes for therapeutic purposes thus overcoming some of the limitations of "conventional" gene therapy. |
Contents
Genetic Modification of Xenografts | 1 |
Public Health Risks Patient vs Society in an Emerging Field | 23 |
R A WEISS | 47 |
G MICHAELS | 73 |
Understanding Xenotransplantation Risks from NonHuman Primate | 101 |
Exogenous Porcine Viruses | 125 |
CrossSpecies Infection and Risk | 185 |
Molecular Cloning and Functional Characterization of Infectious | 217 |
Xenotransplantation Federal Regulatory Considerations | 239 |
| 253 | |
Other editions - View all
Common terms and phrases
Allan anti-HEV antibodies antigen assays baboons capsid cell line clinical clones coronaviruses cross-species cytomegalovirus detected Diagnosis donor encephalitis endogenous retrovirus exogenous gene genetic genome Halbur Halbur PG Heneine hepatitis E virus herds herpesvirus host human cells human HEV infect humans infected pigs infectious disease influenza kidney lesions liver lung macaques Meng XJ molecular monkeys Niebert Nipah virus nonhuman primates organs paramyxovirus Pathogenesis pathogens patients PCV2 PERV piglets PMWS polymerase porcine circovirus porcine endogenous retrovirus porcine parvovirus porcine reproductive potential primates protein PRRSV Pseudorabies public health recipients recombination replication reproductive and respiratory respiratory syndrome virus retroviruses rhesus risk sequence serum simian species strain of human strains of HEV studies swine HEV infection tion tissues transgenic transmission transplantation vaccines viral Virology virus infection virus isolated viruses Weiss RA xeno xenograft xenotransplant xenotransplantation xenotransplantation products Xenozoonoses xenozoonosis zoonotic