Heart development, Volume 342
The development of the cardiovascular system is an exciting and rapidly advancing area of biomedical research, powered by an urgent necessity to reduce the incidence of human cardiovascular disease. It is becoming increasingly clear that many of the congenital pathologies affecting the adult heart will be best understood by tracing their origins in embryonic development. The recent fusion of classical embryology with modern molecular genetics has resulted in an explosion of information about the developing heart in a variety of organisms. A comprehensive knowledge of the control circuitry in the cardiovascular system will form the basis for future advances in genetic therapy and organ culture.
Heart Development presents a collection of chapters written by experts in the field, who describe their current insights into the molecular basis of cardiovascular development. The subject matter from the lineage origins and morphogenesis of the developing cardiovascular system, through genetic dissection of cardiovascular development in a variety of model organism, to the molecular basis of congenital heart defects. Its broad scope will appeal to the generalist or teacher seeking an overview of the subject, while also providing clinicians and medical researchers with comprehensive coverage of the most recent advances.
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in Amphibian Embryos
Vertebrate Heart Induction
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activin activity angioblasts angiogenesis aortic arteries asymmetry atrial atrioventricular atrium avian axis bHLH binding Biol cardiac development cardiac myocytes cardiogenesis Cell Cambridge cell cycle Chen chick embryo cushion cyclin defects deletion Development Cambridge developmental dHAND diac differentiation DiGeorge syndrome domain dorsal Drosophila early eHAND embryogenesis embryos endocardial endoderm endothelial cells epiblast expression patterns formation function gastrulation gene expression Genes Dev Genet growth factor heart development heart field heart tube homeobox gene induced interactions isoforms kinase left-right looping markers MCAT MEF2 mesenchyme mesoderm mice midline migration molecular morphogenesis mouse embryos murine muscle cells mutant myocardial myocardium myogenic myosin Nature London neural crest normal Olson pathway phenotype precardiac precursors primitive streak protein receptor region regulation regulatory retinoic acid right ventricle role segments signaling skeletal muscle smooth muscle somite specific stage syndrome tinman tion tissue transcription factor transgenic vascular vasculogenesis ventral ventricular vertebrate vessels VSMCs Xenopus zebrafish