Glucocorticoid action: basic and clinical implications

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New York Academy of Sciences, 2004 - Medical - 221 pages
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Glucocorticoids regulate multiple metabolic and developmental processes and play a vital role in the maintenance of basal and stress-related homeostasis. For the last 50 years, pharmacologic doses of glucocorticoids have been used in the treatment of inflammatory, autoimmune, and lymphoproliferative diseases and in the prevention of allograft rejection, while substitution doses have been employed in the management of adrenocortical insufficiency. This volume presents the most recent advances in the basic and chrucal aspects of glucocorticoid action, including the impact of maternal and early life stress on stress-related gene regulation in their receptors, further understanding of the mechanisms of GR action, the interaction of hGR with other transcription factors, factors that modulate the function of the GR; an update on the effects of glucocorticoids on the immune system; and the clinicial implications of glucocorticoid action.

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Novel Repression of the Glucocorticoid Receptor by Anthrax Lethal Toxin
Interaction of the Glucocorticoid Receptor with
Physiological and Pathological Consequences of the Interactions of the

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