Complexity in Biological Information Processing
Gregory Bock, Jamie Goode
John Wiley & Sons, Aug 30, 2001 - Medical - 250 pages
Many human diseases arise from the malfunction of signalling components, in particular alterations of multiple components of an integrated signalling network. Experimental and computational tools to describe and quantify these changes are increasingly available, providing a wealth of data that can stimulate systematic analysis of the entire signalling network and enable prediction of disease states not easily recognizable from complex data sets.
This groundbreaking book explores the structural and temporal complexity in biological signalling exemplified in neuronal, immunological, humoral and genetic signal transduction networks. With discussions between experimentalists and theoretically oriented scientists, this book takes an interdisciplinary approach that may help switch the analysis of biological signalling from descriptive to predictive science and capture the behaviour of entire systems.
* Explores the structural and temporal complexity in biological signalling.
* Represents an unusual collocation of three different areas: immunology, cell signalling and neural networks.
* Contains interdisciplinary discussions between experimentalists and theoretically oriented scientists, in particular those working on computer simulations.
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Terence Sejnowski Introduction
Matthias G von Herrath Design of immunebased interventions in autoimmunity
diffuse feedback via a diffuse
General discussion I
Thomas Gudermann Multiple pathways of ERK activation by G proteincoupled
Manuela Zaccolo Luisa Filippin Paulo Magalhaes
Klaus Prank Martin Kropp and Georg Brabant Humoral coding
U Herzig C Cadenas F SieckmannW Sierralta C Thaller A Visel
Simon B Laughlin Efficiency and complexity in neural coding
Ad Aertsen Markus Diesmann MarcOliver Gewaltig Sonja Griin
Rajesh P N Rao and TerrenceJ Sejnowski Predictive learning of temporal
action potential aequorin Aertsen amplitude autoimmune behaviour Berridge Biol brain Brenner Ca2+ Ca2+ signalling Ca2+ spike calcium calmodulin CaMKII cascade cell types cellular channels Complexity in biological components computational concentration cortex cortical CREB cytokines cytoplasm dendrite depends Diesmann direction selectivity disease Dolmetsch dynamics encoding enzyme ERK activation example experimental frequency function gene expression genome GPCR growth factor Herrath hormone hybridization images immune system information processing inhibition inhibitory input InsP3 interactions intracellular Ca2+ kinetics Laughlin learning long-term potentiation lyengar lymphocytes MAP kinase MAPK mechanisms membrane mitochondria modules molecular molecules mouse neural neurons Neurosci Novartis pathogens phosphorylation photoreceptors physiological postsynaptic predict presynaptic protein kinase Rapl receptor recurrent regulation response role RTKs second messenger Segel Sejnowski sequence signal transduction signalling pathways signalling systems spatial specific spike train stimulus stochastic synaptic plasticity synchronous temporal temporal coding tissue transcription transients tyrosine kinase visual