Free Radicals, Oxidative Stress, and Antioxidants: Pathological and Physiological Significance

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Springer Science & Business Media, Apr 30, 1998 - Medical - 395 pages
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There has been an explosion of research related to free radicals and antioxidants in recent years, and hundreds of laboratories worldwide are actively involved in many as pects of free radicals, oxidative stress, and antioxidants. The literature on these topics in creases exponentially every year. Over the last few years, we have been fortunate to witness a widespread recognition of the important role of free radicals in a wide variety of pathological conditions including diseases such as atherosclerosis, cardiovascular and neurological diseases, ischemia, emphysema, diabetes, radiation injury, cancer, etc. In ad dition, many laboratories are studying the role of free radicals in the inexorable process of aging. Increased evidence involves free radicals with the etiology of various diseases, thereby suggesting the use of antioxidants as a viable therapeutic approach for the treat ment of free radical mediated pathologies. Despite these impressive developments, many important aspects of free radical and antioxidant research are open for investigation. It is important to understand the overall mechanisms involved in free radical mediated physiological and pathological conditions. This knowledge will undoubtedly lead to the development of new therapeutic approaches to prevent or control free radical related diseases. This book contains the proceedings of the NATO Advanced Study Institute (ASI) on "Free Radicals, Oxidative Stress, and Antioxidants: Pathological and Physiological Sig nificance," which was held in Antalya, Turkey from May 24-June 4, 1997.
  

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Contents

I
1
II
15
III
25
IV
39
V
51
VI
65
VII
79
VIII
85
XX
195
XXI
205
XXII
229
XXIII
237
XXIV
253
XXV
267
XXVI
285
XXVII
293

X
93
XI
103
XII
109
XIII
121
XIV
131
XV
145
XVI
151
XVII
157
XVIII
163
XIX
189
XXVIII
315
XXXI
323
XXXII
333
XXXIII
343
XXXIV
363
XXXV
375
XXXVI
385
XXXVII
391
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Page 372 - The generation of hydrogen peroxide, superoxide radical and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents. J. Biol. Chem.

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