Molecular GlycobiologyMinoru Fukuda, Ole Hindsgaul Cell-surface carbohydrates play critical roles in cell-cell interactions. This well-written book brings together leading researchers to detail major recent advances regarding our understanding of the molecular mechanisms underlying such processes. Emphasis is given to cell type, specific carbohydrate expression, and the carbohydrates and proteins involved in cell recognition. Topics include the molecular structure of animal lectins, carbohydrate recognition in cell-cell interaction, chemical synthesis of oligosaccharides, conformational studies on oligosaccharides, and cell-surface carbohydrates, among others. Also included is a full discussion of key experimental approaches such as chemical synthesis and the three-dimensional structural analysis of carbohydrates. Providing both an up-to-date description of the subject and a forecast of likely future developments, Molecular Glycobiology is a much-needed synopsis of an exciting and rapidly expanding field. It will be welcomed by students and researchers in molecular biology, biochemistry, cell biology, and glycobiology. |
Contents
List of contributors | 1 |
Mucintype glycans Oglycans | 29 |
B16Nacetylglucosaminyltransferases | 38 |
Copyright | |
12 other sections not shown
Common terms and phrases
a2,6-sialyltransferase a3-Fuc-transferase acceptor activity adhesion molecule affinity amino acid amino acid sequences animal lectins antibody antigen B2-GlcNAc-transferase binding Biochem Biol biosynthesis bovine C-type C-type CRD carbohydrate cDNA encoding cell adhesion cell line cell surface Chem Chinese hamster ovary chromosome cloned coding region complex conformation contain core cytoplasmic disaccharide E-selectin endothelial cells endothelium enzyme epitope erythrocytes exons expression Figure Fuc-transferase fucose fucosylated fucosyltransferase Fukuda functional galactose Galẞ1-4GlcNAc gene genomic DNA GlcNAc GlcNAc-transferase glycans Glycobiology glycolipids glycoproteins glycosylation glycosyltransferases Golgi interaction isolated lectins leukocyte leukocyte adhesion leukosialin ligand lymphocytes lysosomal mammalian Mana1 mannose mannose-binding protein mediated moieties molecular mouse mRNA mucin-type murine N-acetylglucosamine N-acetyllactosamine N-glycans N-linked Natl Acad neutrophils oligosaccharides platelets PNHEV poly-N-acetyllactosamines receptor residues saccharide Schachter selectin Shaper sialic acid sialyl sialyl-Le sialyl-Lex sialyltransferase side chains soluble specific ẞ4-Gal-transferase structure studies substrate sugar synthesis Table tissues transcript transfected transferase transmembrane domain