Cell-surface carbohydrates play critical roles in cell-cell interactions. This well-written book brings together leading researchers to detail major recent advances regarding our understanding of the molecular mechanisms underlying such processes. Emphasis is given to cell type, specific carbohydrate expression, and the carbohydrates and proteins involved in cell recognition. Topics include the molecular structure of animal lectins, carbohydrate recognition in cell-cell interaction, chemical synthesis of oligosaccharides, conformational studies on oligosaccharides, and cell-surface carbohydrates, among others. Also included is a full discussion of key experimental approaches such as chemical synthesis and the three-dimensional structural analysis of carbohydrates. Providing both an up-to-date description of the subject and a forecast of likely future developments, Molecular Glycobiology is a much-needed synopsis of an exciting and rapidly expanding field. It will be welcomed by students and researchers in molecular biology, biochemistry, cell biology, and glycobiology.
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Celltype specific expression of ATglycans
Mucintype glycans Oglycans
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a2,6-sialyltransferase a3-Fuc-transferase a3-Gal-transferase acceptor activity adhesion molecule affinity amino acid amino acid sequences animal lectins antibody antigen asialoglycoprotein binding Biochem Biol biosynthesis bovine C-type C-type CRDs carbohydrate cDNA encoding cell adhesion cell line cell surface Chem Chinese hamster ovary chromosome cloned coding region complex conformation contain core cytoplasmic E-selectin endothelial cells endothelium enzyme epitopes erythrocytes exons expression Figure Fuc-transferase fucose fucosylated fucosyltransferase Fukuda functional galactose gene genomic DNA GlcNAc GlcNAc-transferase GlcNAcpl GlyCAM-1 glycans Glycobiology glycolipids glycoproteins glycosylation glycosyltransferases Golgi homologous interaction isolated lectins leukocyte leukocyte adhesion leukosialin ligand lymphocytes lysosomal mammalian mannose mannose-binding protein mediated moieties molecular mouse mRNA mucin-type murine myeloid cells N-acetylglucosamine N-acetyllactosamine N-glycans Natl Acad neutrophils oligosaccharides p2-GlcNAc-transferase plasmid platelets PNHEV poly-N-acetyllactosamines receptor residues saccharide Schachter selectin Shaper sialic acid sialyl sialyl-Lex sialyltransferase side chains soluble specific structure studies substrate sugar synthesis Table tissues transcript transfected transferase transmembrane domain