The didactic presentation of the material makes this book an essential bench-top tool not only for specialists in organic chemistry, but also for students & all those involved in the preparation of organic molecules. Key Features: - a critical survey of the most used protecting groups, as used by organic chemists - organization based on functional groups: hydroxyl ; diol; carbonyl; carboxyl; amine - special emphasis placed on deprotection conditions applied to complex structures where selectivity is a prime issue - transformations accompanied by key experimental details - examples from the recent literature span a wide domain of organic synthesis - over 500 schemes aid visual retrieval - end-of-chapter list reviews which amplify topics covered.
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13C NMR accomplished acylation alcohol aldehydes alkylation allyl amines amino Angew aqueous asymmetric synthesis benzyl benzyl ethers benzylidene acetals carbamates Carbohydr carboxylic acid catalyst CF3COOH Chem Chemistry chloride cleavage cleaved COOH COOMe Corey deprotection derivatives dioxane dioxolane DMAP Engl enol equiv esterification esters EtOH example Fmoc formation functional groups HOAc hydrogenolysis hydrolysis hydroxyl hydroxyl groups imidazole intermediate isopropylidene ketones labile Lewis acids Liebigs Ann MeCN MeOH metal method methyl ethers mild mmol scale nucleophilic OH OH OMe OMe OMe Scheme OMOM Organic Synthesis Ortho Esters orthogonal set OSiMe2Bu OSiPh2Bu oxidation Pd-C peptide Perkin Trans phenol prepared presence protecting groups PTSA reaction reactive reagents reduction removed Reviews Concerning ring selective shown in Scheme silyl ethers SiMe3 stable steric substrates Synth synthetic TBAF TBS ethers tert-butyl ester Tetrahedron Lett yield