Protein Folding: A Discussion

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Christopher M. Dobson, Alan Fersht
Cambridge University Press, 1996 - Science - 119 pages
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A discussion organized and edited by C. M. Bobson and A. R. Fersht. Disulphide-coupled protein folding pathways. (T. Creighton). Mapping the structures of transition states and intermediates in folding: delineation of pathways at high resolution. (A. R. Fersht). Insights into protein folding using physical techniques: studies of lysozyme and a-lactalbumin. (Sheena E. Radford and Christopher M. Dobson). Initial studies of the equilibrium folding pathway of staphysilococcal nuclease. (Yi Wang, Andrei T. Alexandrescu and David Shortle). Kinetic and equilibrium folding intermediates. (O. B. Ptitsyn, V. E. Bychkova and V, N, Uversky). Does the molten globule have a native-like tertiary fold? (Zheng-Yu Peng, Lawren C. Wu, Brenda A. Schulman and Peter S. Kim). Investigation of protein unfolding and stability by computer simulation. (W. F. van Gunsteren, P. H. Hunenberber, H. Kovacs, A. E. Mark and C. A. Schiffer). Models of cooperativity in protein folding. (Hue Sun Chan, Sarina Bromberg and Ken A. Dill). Protein folds: towards understanding folding from inspection of native structures. (Janet M. Thornton, david T. Jones, Malcolm W. MacArthur, Christine M. Orengo and Mark B. Swindells). Design of two-stranded and three-stranded coiled-coil peptides. (Stephen Betz, Robert Fairman, Karyn O'Neil, james Lear and Willian DeGrado). Nascent chains: folding and chaperone interaction during elongation on ribosomes. (Kostas Tokatlidis, Bertrand Friguet, Dominique Deville-Bonne, François Baleux, Alexey N. Fedorov, Amiel Navon, Lisa Djavadi-Ohaniance and Michel E. Goldberg). Folding and association versus misfolding and aggregation of proteins. (Rainer Jaenicke). Principles of chaperone-mediated protein folding. (F. Ulrich Hartl). Unliganded GroEL at 2.8 A: structure and functional implications. (Paul B. Sigler and Arthur L. Horwich).
  

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Contents

Disulphidecoupled protein folding pathways
5
delineation of pathways at high resolution
11
studies of lysozyme and 𝛼lactalbumin
17
Initial studies of the equilibrium folding pathway of staphylococal nuclease
27
Kinetic and equilibrium folding intermediates
35
Does the molten globule have a nativelike tertiary fold?
43
Investigation of protein unfolding and stability by computer simulation
49
Models of cooperativity in protein folding
61
towards understanding folding from inspection of native structures
71
Design of twostranded and threestranded coiledcoil peptides
81
folding and chaperone interaction during elongation on ribosomes
89
Folding and association versus misfolding and aggregation of proteins
97
Principles of chaperonemediated protein folding
107
structure and functional implications
113
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